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Philadelphia Eagles v Green Bay Packers Newly Relocated Colts QB Carson Wentz Expected to Have ‘Greater Production’ in 2021 We’ve all been waiting for Wentz to return to the MVP-caliber form we witnessed in 2017, and I think we’ll begin to see something closer to it now that he’s reunited with his old offensive coordinator in Frank Reich. After a tough, three-year decline in Philly, Wentz is set up to turn the corner in Indy behind a premier offensive line and with a dominant run game and more established weapons in the passing game. Reich has routinely put his quarterbacks in position to succeed by getting the ball out of the passer’s hands and leaning on young talent in the run game to open up the aerial attack. Wentz won’t be running for his life (sacked a league-high 50 times last season despite playing just 12 games), and having better protection alone should allow him stay on schedule with his throws and regain confidence in his skills as a passer. 2021 projection: 62 comp. percentage, 3,100 pass yards, 23 TDs, 14 INTs The former Philadelphia Eagles franchise quarterback should benefit from a desperately needed change of scenery in Indianapolis and a much anticipated reunion with Colts head coach Frank Reich —as the two have shared prior success together. Not only should Reich’s ‘quarterback friendly’ offense maximize Wentz’s strengths and mitigate his weaknesses—allowing for an uptick in potential production, but he’ll also benefit from a stronger Colts supporting cast—which features a stalwart offensive line and a power running game led by emerging superstar rusher Jonathan Taylor . In the process, under Reich’s tutelage, Wentz will need to clean up clicking here some acquired bad habits with his passing mechanics and regain some of his lost confidence/swagger. As a former NFL quarterback himself, Reich may know better than almost anyone in what makes the 2nd overall pick of the 2016 NFL Draft truly tick and how he can recapture his tantalizing 2017 form when he was a bonafide NFL MVP Candidate. That special season, Wentz was a stud, having thrown for 33 touchdowns to just 7 interceptions for the then 11-2 Eagles—before suffering a season-ending torn ACL. He hasn’t really been the same star quarterback since, as his shine has faded. That being said, the support system is there for Wentz to thrive for the Colts—with the right adjustments and proper mindset. He’s still only 28 years old and the dynamic talent is there to untap. For what it’s worth, retired Colts starting quarterback Philip Rivers completed 369 of 543 throws (68.0%) for 4,169 passing yards, 24 touchdowns, and 11 interceptions during all 16 starts this past season. While the anticipated drop in accuracy is understandable ( as Rivers had an all-time great season regarding his completion percentage ), the roughly 1,000 less total passing yards is interesting to say the least—and I just don’t see it if Wentz starts all 17 games for Indy. If anything, even if there is a realistic drop in accuracy from his predecessor, as Wentz takes more shots downfield and riskier chances (rather than electing for the safer underneath/checkdown routes), it wouldn’t be surprising if Wentz also has 25-30 passing touchdowns—while still throwing for 4,000+ passing yards. That is, if everything truly clicks for the new Colts quarterback.


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Four key concerns stemming from the emergence of the new variants are their effects on viral transmissibility, disease severity, reinfection rates (i.e., escape from click this link natural immunity), and vaccine effectiveness (i.e., escape from vaccine-induced immunity). The 501Y.V2 variant spread rapidly in South Africa, accounting for 11% of the viruses sequenced (44 of 392) in the first week of October 2020, for 60% of those sequenced (302 of 505) in the first week of November 2020, and for 87% of those sequenced (363 of 415) in the first week of December 2020. In Western Cape, a South African province where the 501Y.V2 variant is predominant, a threshold of 100,000 cases of Covid-19 was reached approximately 50% more quickly in the second wave of infection than in the first wave (54 vs. 107 days). The 501Y.V2 variant has been estimated to be 50% 2 more transmissible than preexisting variants in South Africa, and B.1.1.7 to be between 43% and 82% 3 more transmissible than preexisting variants in the United Kingdom. Hospital admission rates of diagnosed cases and the clinical profile of admitted patients were similar in the first and second waves in Western Cape. However, a preliminary analysis by the National Institute of Communicable Diseases showed that the 501Y.V2 variant was associated with in-hospital mortality that was 20% higher in the second wave in South Africa than in the first wave. This finding was due mainly to the greater transmissibility of this variant, which rapidly overburdened health services and thus compromised timely access to hospital care and the quality of that care. Evidence from the United Kingdom indicates that the B.1.1.7 variant may be associated with a higher risk of death than preexisting variants in the United Kingdom. 4 Although there is no evidence that antiviral agents and antiinflammatory treatments are any less effective with the emerging variants than with the preexisting variants, treatment with convalescent serum and monoclonal antibodies may not be as effective. With regard to escape from natural immunity, the B.1.1.7 variant showed a modest decrease in neutralization activity, by a factor of 1.5, whereas the 501Y.V2 variant showed complete escape from neutralizing antibodies in 48% of convalescent serum samples (21 of 44) obtained from patients who had previously had Covid-19. 5 A serendipitous finding from a vaccine trial in South Africa, in which 31% of the enrolled participants had previously been infected with SARS-CoV-2, was that the incidence of Covid-19, as confirmed on polymerase chain reaction, was 7.9% among seronegative enrollees and 4.4% among seropositive enrollees in the placebo group. This finding indicates that previous infection with preexisting variants may provide only partial protection from reinfection with the 501Y.V2 variant. Summary Results on SARS-CoV-2 Vaccine Trial Efficacy and Viral Neutralization of the B.1.1.7, P.1, and 501Y.V2 Variants, as Compared with Preexisting Variants. With regard to escape from vaccine-induced immunity, the B.1.1.7 variant showed modest decreases in neutralizing activity in serum samples obtained from vaccinated persons ( Table 1 ). The serum neutralizing activity for the 501Y.V2 variant among vaccinated persons was lower by a factor of 1.6 to 8.6 for the BBIBP-CorV vaccine, the BNT162b2 vaccine, and the mRNA-1273 vaccine but was lower by a factor of up to 86, including complete immune escape, for the AZD1222 vaccine ( Table 1 ). Neutralizing activity for the P.1 variant among vaccinated persons was lower by a factor of 6.7 for the BNT162b2 vaccine and by a factor of 4.5 for the mRNA-1273 vaccine ( Table 1 ). The clinical relevance of the lower neutralization activity for either mild or severe Covid-19 is not clear, but efficacy in clinical trials was lower for all three vaccines tested in the midst of transmission of the 501Y.V2 variant in South Africa than efficacy in trials conducted in countries with preexisting variants. Efficacy was higher by a factor of 3.2 with the AZD1222 vaccine in the United Kingdom and Brazil than in South Africa (70% vs.